Hep

Tratament ARC 520

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Trimis: Sun Feb 21, 2016 1:52 pm Titlul subiectului: Tratament ARC 520 Raspunde cu citat (quote) Din cate am citit arc 520 arata cele mai promitatoare rezultate in cea ce priveste eliminarea AgHbs, se ajunge pana la 99,99 %
Ce inseamna asta?
Presented data at the AASLD Liver Meeting 2015 including the following:
ARC-520 led to robust, sustained anti-viral effects in chimpanzees with chronic HBV, and we also described an important new discovery that HBV DNA integrated into the host genome is likely an important source of HBV surface antigen (HBsAg) production
In a Phase 2a clinical study, ARC-520 effectively reduced HBV viral antigens derived from cccDNA. HBsAg was reduced substantially with a maximum reduction of 1.9 logs (99%) and a mean maximum reduction of 1.5 logs (96.8%) in treatment naïve e-antigen (HBeAg)-positive patients
Presented data at Hep DART 2015 showing that ARC-520 led to immune reactivation in 7 of 9 chimpanzees with chronic hepatitis B infection
Began dosing in the Phase 2b MONARCH combination study

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sakuraba1987
  • Data inscrierii: 29/Mar/2015
  • Mesaje: 5

Trimis: Sun Feb 21, 2016 1:54 pm Titlul subiectului: Raspunde cu citat (quote) ce inseamna immune reactivation. Asta s-a produs la 7 cimpanzei din 9 in testele clinice. S-a eliminat Ag Hbs in totalitate si s-au creat anticorpii Anti Hbs?
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sakuraba1987
  • Data inscrierii: 29/Mar/2015
  • Mesaje: 5

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